Press Releases and Articles


Contact: Jessica Yingling, Little Dog Communications
jessica@litldog.com

Press Releases and Articles

Fri Jan 10

Empirico Inks Drug Target Discovery Alliance With Antisense Drug Firm Ionis

GENOMEWEB—Empirico said on Thursday that it has formed a drug discovery alliance with antisense therapeutics firm Ionis Pharmaceuticals.

As part of the deal, Ionis has taken a $10 million stake in Empirico, which also announced the close of a $17 million Series A-2 financing round.

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Thu Jan 9

Empirico Announces Strategic Collaboration to Harness Human Genetics for the Discovery and Development of Novel Antisense Oligonucleotide Therapeutics

SAN DIEGO, January 9, 2020 — Empirico Inc. announced today that it has entered into a strategic collaboration with Ionis Pharmaceuticals. During the three-year collaboration, Empirico will utilize its Precision Insights Platform, which incorporates huge biological data sets, human genetics and advanced algorithmic approaches, to identify therapeutic targets for indications and tissues that are amenable to Ionis’ industry-leading antisense technology.
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Thu Jan 9

Ionis finds new partner in a young biotech and its hopeful founder

ENDPOINTS NEWS—Omri Gottesman came to the US from the UK 10 years ago, wide-eyed like many others.

The human genome project was long-complete and, with great fanfare, researchers were beginning to try and leverage those insights into treatments. Mount Sinai School of Medicine offered him a fellowship focused on just that: genomic medicine. Continue reading “Ionis finds new partner in a young biotech and its hopeful founder”

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Thu Jan 9

Empirico Raises $17M, Inks 3-Year Antisense Collaboration with Ionis

Xconomy San Diego —Empirico, a biotech that has developed tools to analyze genomics data and use those insights to identify potential therapeutic targets, has signed a collaboration deal with antisense drug developer Ionis Pharmaceuticals that includes a $10 million equity investment.

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Thu Jan 9

Empirico scores $660M deal with Ionis and lands a series A-2 fundraiser

BIOWORLD—It’s a big day for privately held Empirico Inc. as it embarks on a massive combo pharma deal with Ionis Pharmaceuticals Inc. while racking up a $12.5 million series A-2 financing.

In the collaboration, Empirico will identify the targets and Ionis can advance as many as 10 of them. The two companies plan to use human genetics data in their efforts with programs Ionis already has in the works, and that includes target validation, the indication and biomarker selection, and patient stratification.

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Thu Jan 9

Deals with Empirico and Aro to help Ionis bring new targets, tissues to early-stage pipeline

BIOCENTURY—Ionis is turning to two young biotechs to build off the success of its antisense oligonucleotides and expand the reach of its platform. The company announced a pair of deals with Empirico and Aro on Thursday, designed to bring antisense therapeutics into new tissues and indications.

Continue reading “Deals with Empirico and Aro to help Ionis bring new targets, tissues to early-stage pipeline”

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Mon Jan 6

Data Engineer

Position Title: Data Engineer

Location: San Diego, CA

Position Description: Empirico, an early-stage biotechnology company, is looking for a talented data engineer that is motivated by the opportunity to develop cutting edge data architectures that allow our scientists to discover new medicines.  You will work closely with scientists and engineers that have a passion for building out novel systems and approaches toward the treatment and prevention of disease.

Responsibilities:

Your responsibilities will focus around the design, implementation, and deployment of modern data infrastructure, methods, pipelines, and applications.  You will be expected to:

  • Collaborate closely with an interdisciplinary team of scientists and engineers to design, develop, and deploy robust data pipelines that analyze huge biological datasets.
  • Take on complex data-related problems using the largest genetic and phenotypic datasets available
  • Identify and resolve performance bottlenecks and pain points throughout our data infrastructure
  • Enhance and support our platform as it scales

Requirements:

  • S, M.S, Ph.D. in computer science, engineering, mathematics, or equivalent industry experience
  • Strong technical skillset that spans a broad range of technologies, programming languages, and paradigms
  • Proficient with multiple programming languages (preferably Scala, Python, and/or Java)
  • Experience processing, modeling, and analyzing large and heterogenous datasets
  • Experience with distributed data processing technologies (Spark, Hadoop, etc.)
  • Familiarity with cloud computing (AWS, Azure, or GCP)
  • Experience and familiarity with genetic, clinical, and phenotypic data, including standard formats a plus
  • Demonstrated ability for writing readable, testable, and SOLID code

Empirico is a venture-backed, next-generation therapeutics company founded on utilizing huge biological datasets, human genetics and programmable biology to power novel target discovery and development. Empirico’s Precision Insights Platform was purpose-built for therapeutic discovery and leverages a world-leading dataset and advanced algorithmic approaches to identify and prioritize therapeutic targets with a high probability of translational success. High priority therapeutic targets are experimentally validated in-house prior to progressing through pre-clinical development with the most optimal therapeutic modality. Empirico is headquartered in San Diego, CA with laboratories in Madison, WI.

To all agencies: Please do not contact any employee of Empirico about this position. All resumes submitted by agencies to any employee of Empirico via-email or in any form and by any method will be deemed the sole property of Empirico, unless such agencies were engaged by Empirico for this position and a valid agreement is in place.

Empirico is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

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Mon Nov 11

Program and Alliance Manager

Location: San Diego, CA

Position Description: Empirico, an early-stage biotechnology company, is looking for a Program and Alliance Manager to provide operational leadership across a number of early-stage therapeutic programs and collaborations with external parties. This is an excellent opportunity for a highly-motivated, creative and organized scientist to be a vital member of a team of experts dedicated to identifying new disease targets and translating those insights into therapeutic programs.

Responsibilities:

Your responsibilities will include monitoring and driving the execution of program and collaboration goals and deliverables. You will be expected to:

  • Collaboratively develop, track and manage project plans for internal programs
  • Coordinate project tasks and deliverables across internal teams and external service providers
  • Contribute to resource planning, financial and capacity assessments
  • Organize and lead internal and external meetings including agenda, materials and action items
  • Manage and track interactions and deliverables with external partners and collaborators
  • Regularly communicate accurate project progress
  • Anticipate potential risks or delays, act to minimize them and develop backup strategies
  • Identify opportunities for process improvements and collaborate to implement them

Requirements:

  • This position requires a MS or PhD in life sciences with experience in program management in the biotech/pharmaceutical industry
  • Familiarity with the process, language and tools of drug discovery and development
  • Excellent written, verbal and interpersonal communication skills
  • Exceptional organizational and time management skills and the ability to multi-task several projects at once
  • Proficiency in Excel, PowerPoint, Word and project management tools
  • Applicants must have authorization to work in the U.S.

Empirico is a venture-backed, next-generation therapeutics company founded on utilizing huge biological datasets, human genetics and programmable biology to power novel target discovery and development. Empirico’s Precision Insights Platform™ was purpose-built for therapeutic discovery and leverages a world-leading dataset and advanced algorithmic approaches to identify and prioritize therapeutic targets with a high probability of translational success. High priority therapeutic targets are experimentally validated in-house prior to progressing through pre-clinical development with the most optimal therapeutic modality. Empirico is headquartered in San Diego, CA with laboratories in Madison, WI.

To all agencies: Please do not contact any employee of Empirico about this position. All resumes submitted by agencies to any employee of Empirico via-email or in any form and by any method will be deemed the sole property of Empirico, unless such agencies were engaged by Empirico for this position and a valid agreement is in place.

Empirico is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

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Tue Oct 15

Software Engineer – Full Stack

Location: San Diego, CA

Position Description: Empirico, an early-stage biotechnology company, is looking for a talented software engineer that is motivated by the opportunity to build applications and user interfaces that empower our scientists to discover new medicines.

Responsibilities:

Your responsibilities will focus around the design and development of functional and elegant scientific applications and user interfaces.  You will be expected to:

  • Collaborate with a team of scientists and engineers to design, implement, and enhance applications and services that are critical to our scientific workflow
  • Take an active role in defining the look, feel, and function of our platform
  • Quickly take new ideas from mockup, to prototype, to a quality application or enhancement
  • Identify and solve problems all along the stack
  • Uphold a high standard of user experience, code quality, testing

Requirements:

  • 2+ years of industry experience designing and developing modern web applications
  • Sound knowledge of software design and architecture
  • Deep understanding of JavaScript, as well as experience with modern frameworks like React
  • Experience developing server-side code in an object-oriented or functional programming language
  • Experience with continuous integration/continuous deployment and container frameworks
  • Experience visualizing complex data in real-time a plus
  • Experience working with cloud services a plus
  • Functional programming experience a plus
  • Experience with Scala and Play Framework a plus
  • Preferably able to provide links to relevant open source projects or contributions
  • Applicants must have authorization to work in the U.S.

Empirico is a venture-backed, next-generation therapeutics company founded on utilizing huge biological datasets, human genetics and programmable biology to power novel target discovery and development. Empirico’s Precision Insights Platform™ was purpose-built for therapeutic discovery and leverages a world-leading dataset and advanced algorithmic approaches to identify and prioritize therapeutic targets with a high probability of translational success. High priority therapeutic targets are experimentally validated in-house prior to progressing through pre-clinical development with the most optimal therapeutic modality. Empirico is headquartered in San Diego, CA with laboratories in Madison, WI.

To all agencies: Please do not contact any employee of Empirico about this position. All resumes submitted by agencies to any employee of Empirico via-email or in any form and by any method will be deemed the sole property of Empirico, unless such agencies were engaged by Empirico for this position and a valid agreement is in place.

Empirico is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

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Mon Oct 14

Lead Engineer – Engineering Operations

Location: San Diego, CA or Remote

Position Description: Empirico, an early-stage biotechnology company, is looking for a talented software engineer that is motivated by the opportunity to design and build systems that make our data-driven methods of discovering new medicines more efficient.  This role requires close collaboration with a team of engineers and computational scientists working on large-scale, cloud-based infrastructure.

Responsibilities:

Your responsibilities will focus around designing and implementing robust and extensible infrastructure that supports critical engineering and scientific processes.  You will be expected to:

  • Spearhead the design and implementation of systems and tools that accelerate the development, testing, and deployment of mission critical infrastructure, applications, and workflows.
  • Integrate and take ownership of a modernized operations toolchain
  • Collaborate closely with an interdisciplinary team of scientists and engineers to address system pain points
  • Integrate metrics systems that allow us to monitor and make data driven decisions to improve platform performance
  • Advocate for systems and engineering practice improvements

Requirements:

  • 3+ years designing and developing modern infrastructure systems and tools
  • Experience operating and maintaining large distributed systems
  • Strong technical skillset that spans a broad range of technologies, programming languages, and paradigms
  • Passionate about systems thinking and drive towards elegant and automated solutions to operational problems
  • Must be able to provide links to relevant open source code, contributions, or publications
  • Applicants must have authorization to work in the U.S.

Empirico is a venture-backed, next-generation therapeutics company founded on utilizing huge biological datasets, human genetics and programmable biology to power novel target discovery and development. Empirico’s Precision Insights Platform™ was purpose-built for therapeutic discovery and leverages a world-leading dataset and advanced algorithmic approaches to identify and prioritize therapeutic targets with a high probability of translational success. High priority therapeutic targets are experimentally validated in-house prior to progressing through pre-clinical development with the most optimal therapeutic modality. Empirico is headquartered in San Diego, CA with laboratories in Madison, WI.

To all agencies: Please do not contact any employee of Empirico about this position. All resumes submitted by agencies to any employee of Empirico via-email or in any form and by any method will be deemed the sole property of Empirico, unless such agencies were engaged by Empirico for this position and a valid agreement is in place.

Empirico is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

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Fri Jun 7

Assistant Scientist – In Vitro Validation

Location: Madison, WI

Position Description: Empirico, an early-stage biotechnology company, is looking for an assistant scientist with a strong background in performing mammalian tissue culture and cell-based assays for the purposes of understanding gene function. This is an excellent opportunity for an experienced scientist that desires to make meaningful contributions in the discovery and validation of new therapeutic targets. You will work closely with other scientists that have a passion for finding novel approaches toward the treatment and prevention of disease.

Responsibilities:

Your responsibilities will include establishing and performing a wide variety of cell-based and molecular biological assays designed to provide insights into gene function. The ideal candidate will also have extensive experience in quantitative protein-based and nucleic acid-based detection systems, be highly organized, and enjoys working in a team environment. You will be expected to:

  • Perform a wide variety of cell-based assays
  • Aid in the creation of experimental protocols and SOPs
  • Maintain detailed experimental records
  • Analyze and communicate experimental results
  • Perform general laboratory duties including the ordering of reagents/supplies
  • Be a team player who enjoys an open environment where you can contribute in highly meaningful and impactful ways

Requirements:

  • B.S in molecular biology, biochemistry or related field with 2+ years of experience in a laboratory setting
  • Hands on experience using and manipulating mammalian tissue culture systems
  • Working knowledge of reporter gene systems, ELISA, AlphaLISA, RT-qPCR, gel electrophoresis
  • Proficient in MS Word, Excel and PowerPoint
  • Experience in advanced cell culture systems (e.g. air-liquid interface) is a plus
  • Previous industry experience is preferred
  • Applicants must have authorization to work in the U.S.

Empirico is a venture-backed, next-generation therapeutics company founded on utilizing huge biological datasets, human genetics and programmable biology to power novel target discovery and development. Empirico’s Precision Insights Platform™ was purpose-built for therapeutic discovery and leverages a world-leading dataset and advanced algorithmic approaches to identify and prioritize therapeutic targets with a high probability of translational success. High priority therapeutic targets are experimentally validated in-house prior to progressing through pre-clinical development with the most optimal therapeutic modality. Empirico is headquartered in San Diego, CA with laboratories in Madison, WI.

To all agencies: Please do not contact any employee of Empirico about this position. All resumes submitted by agencies to any employee of Empirico via-email or in any form and by any method will be deemed the sole property of Empirico, unless such agencies were engaged by Empirico for this position and a valid agreement is in place.

Empirico is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

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Wed May 1

Assistant Scientist – Assay Systems

Location: Madison, WI

Position Description: Empirico, an early-stage biotechnology company, is looking for an assistant scientist with a strong background in performing biomarker assays. This is an excellent opportunity for an experienced scientist that desires to make meaningful contributions in the discovery and validation of new therapeutic targets. You will work closely with other scientists that have a passion for finding novel approaches toward the treatment and prevention of disease.

Responsibilities:

Your responsibilities will include establishing and performing a wide variety of biochemical and molecular biological assays designed to provide insights into gene function in in vitro and cell culture models. The ideal candidate will have extensive experience in both protein-based and nucleic acid-based assay systems, be highly organized, and enjoys working in a team environment. You will be expected to:

  • Perform a wide variety of biomarker assays
  • Aid in the creation of experimental protocols and SOPs
  • Maintain detailed experimental records
  • Analyze and communicate experimental results
  • Perform general laboratory duties including the ordering of reagents/supplies
  • Be a team player who enjoys an open environment where you can contribute in highly meaningful and impactful ways

Requirements:

  • B.S. in molecular biology, biochemistry or related field with 2+ years of experience in a laboratory setting
  • Hands on experience of assay systems including ELISA, AlphaLISA, RT-qPCR, reporter gene systems, Luminex
  • Proficient in MS Word, Excel and Powerpoint
  • Experience in cell culture techniques is a plus
  • Previous industry experience is preferred
  • Applicants must have authorization to work in the U.S.

Empirico is a venture-backed, next-generation therapeutics company founded on utilizing huge biological datasets, human genetics and programmable biology to power novel target discovery and development. Empirico’s Precision Insights Platform™ was purpose-built for therapeutic discovery and leverages a world-leading dataset and advanced algorithmic approaches to identify and prioritize therapeutic targets with a high probability of translational success. High priority therapeutic targets are experimentally validated in-house prior to progressing through pre-clinical development with the most optimal therapeutic modality. Empirico is headquartered in San Diego, CA with laboratories in Madison, WI.

To all agencies: Please do not contact any employee of Empirico about this position. All resumes submitted by agencies to any employee of Empirico via-email or in any form and by any method will be deemed the sole property of Empirico, unless such agencies were engaged by Empirico for this position and a valid agreement is in place.

Empirico is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

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Wed May 1

Scientist / Sr. Scientist – Translational Genetics

Location:  San Diego, CA

Position Description: Empirico, an early-stage biotechnology company, is looking for a scientist-level computational geneticist experienced in analyzing and interpreting large scale human genetics data for the purpose of therapeutic target discovery. This is an excellent opportunity for a highly-motivated, creative scientist to be a vital member of a team of experts dedicated to identifying new disease targets and translating those insights into therapeutic programs.

Responsibilities:

Your responsibilities will include using human genetics data to identify new therapeutic targets in order to advance Empirico’s drug discovery and development pipeline. You will be expected to:

  • Work with a multidisciplinary team consisting of human geneticists, biologists, bioinformaticians and software engineers to assist in the design, execution, and interpretation of in silico genetics studies
  • Utilize existing knowledge and develop expertise in the biology and pathophysiology of identified targets and relevant diseases
  • Translate findings from genetic studies into therapeutic hypotheses and contribute to decisions around therapeutic modality and targeting strategies
  • Collaborate with biologists and chemists on the design of in vitro and in vivo experiments to validate therapeutic hypotheses that are motivated by human genetics findings
  • Survey the latest developments in the broader genetics community and incorporate relevant approaches for internal studies
  • Provide novel ideas and critical thinking for the continued development and improvement of Empirico’s target discovery platform
  • Communicate and report genetic findings and analyses with colleagues, collaborators, investors and through peer-reviewed publication

Requirements:

  • This position requires an MD or PhD with 0-3 years of postgraduate experience in human genetics research with a translational focus. Recent graduates and postdocs encouraged to apply.
  • Demonstrated ability to design and interpret human genetics studies and to discern therapeutic hypotheses
  • A firm understanding of the principles of statistical genetics and genetic epidemiology
  • Familiarity with the design of functional studies to understand the mechanistic basis for genetic associations
  • Applicants must have authorization to work in the U.S.

Empirico is a venture-backed, next-generation therapeutics company founded on utilizing huge biological datasets, human genetics and programmable biology to power novel target discovery and development. Empirico’s Precision Insights Platform™ was purpose-built for therapeutic discovery and leverages a world-leading dataset and advanced algorithmic approaches to identify and prioritize therapeutic targets with a high probability of translational success. High priority therapeutic targets are experimentally validated in-house prior to progressing through pre-clinical development with the most optimal therapeutic modality. Empirico is headquartered in San Diego, CA with laboratories in Madison, WI.

To all agencies: Please do not contact any employee of Empirico about this position. All resumes submitted by agencies to any employee of Empirico via-email or in any form and by any method will be deemed the sole property of Empirico, unless such agencies were engaged by Empirico for this position and a valid agreement is in place.

Empirico is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

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Fri Apr 12

Associate Director / Director – Translational Genetics

Location:  San Diego, CA

Position Description: Empirico, an early-stage biotechnology company, is looking for a director-level computational geneticist experienced in analyzing and interpreting large scale human genetics data for the purpose of therapeutic target discovery. This is an excellent opportunity for a highly-motivated, creative scientist to be a vital member of a team of experts dedicated to identifying new disease targets and translating those insights into therapeutic programs.

Responsibilities:

Your responsibilities will include using human genetics data to identify new therapeutic targets in order to advance Empirico’s drug discovery and development pipeline. You will be expected to:

  • Work with a multidisciplinary team consisting of human geneticists, biologists, bioinformaticians and software engineers to lead the design, execution, and interpretation of in silico genetics studies
  • Utilize existing knowledge and develop expertise in the biology and pathophysiology of identified targets and relevant diseases
  • Translate findings from genetic studies into therapeutic hypotheses and contribute to decisions around therapeutic modality and targeting strategies
  • Collaborate with biologists and chemists on the design of in vitro and in vivo experiments to validate therapeutic hypotheses that are motivated by human genetics findings
  • Survey the latest developments in the broader genetics community and incorporate relevant approaches for internal studies
  • Provide novel ideas and critical thinking for the continued development and improvement of Empirico’s target discovery platform
  • Communicate and report genetic findings and analyses with colleagues, collaborators, investors and through peer-reviewed publication

Requirements:

  • This position requires an MD or PhD with at least 4-6 years of postgraduate experience in human genetics research with a translational focus. Pay and title commensurate with experience.
  • Demonstrated ability to design, lead and interpret human genetics studies and to discern therapeutic hypotheses
  • A firm understanding of the principles of statistical genetics and genetic epidemiology
  • Familiarity with the design of functional studies to understand the mechanistic basis for genetic associations
  • Applicants must have authorization to work in the U.S.

Empirico is a venture-backed, next-generation therapeutics company founded on utilizing huge biological datasets, human genetics and programmable biology to power novel target discovery and development. Empirico’s Precision Insights Platform™ was purpose-built for therapeutic discovery and leverages a world-leading dataset and advanced algorithmic approaches to identify and prioritize therapeutic targets with a high probability of translational success. High priority therapeutic targets are experimentally validated in-house prior to progressing through pre-clinical development with the most optimal therapeutic modality. Empirico is headquartered in San Diego, CA with laboratories in Madison, WI.

To all agencies: Please do not contact any employee of Empirico about this position. All resumes submitted by agencies to any employee of Empirico via-email or in any form and by any method will be deemed the sole property of Empirico, unless such agencies were engaged by Empirico for this position and a valid agreement is in place.

Empirico is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

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